Subgingival bacteria are continually exposed to gingival crevicular fluids that are derived from serum, which contain various\nbactericidal agents. The periodontopathic bacterium Porphyromonas gingivalis has been demonstrated to possess a variety of\nabilities to resist bactericidal agents, due towhich it is able to propagate in the subgingival environment.We previously demonstrated\nthat the major surface glycoproteins of P. gingivalisâ??Pgm6 and Pgm7, also called outer membrane protein A-like proteins\n(OmpALPs)â??mediate resistance to the bactericidal activity of human serum, but their precise role remains unknown. In this study,\nwe investigated the sensitivity of the wild-type and Pgm6/Pgm7-deficient P. gingivalis strains toward major antimicrobial peptides\nin the oral cavity, human.............
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